Bioactive compounds derived from hops (humulus Lupulus L.)

Scientific References;

1: Obara K, Mizutani M, Hitomi Y, Yajima H, Kondo K. Isohumulones, the bitter
component of beer, improve hyperglycemia and decrease body fat in Japanese
subjects with prediabetes. Clin Nutr. 2009 Jun;28(3):278-84. Epub 2009 Apr 23.
PubMed PMID: 19395131.

2: Namikoshi T, Tomita N, Fujimoto S, Haruna Y, Ohzeki M, Komai N, Sasaki T,
Yoshida A, Kashihara N. Isohumulones derived from hops ameliorate renal injury
via an anti-oxidative effect in Dahl salt-sensitive rats. Hypertens Res. 2007
Feb;30(2):175-84. PubMed PMID: 17460388.

3: Shimura M, Hasumi A, Minato T, Hosono M, Miura Y, Mizutani S, Kondo K, Oikawa
S, Yoshida A. Isohumulones modulate blood lipid status through the activation of
PPAR alpha. Biochim Biophys Acta. 2005 Sep 5;1736(1):51-60. PubMed PMID:
16099209.

4: Yajima H, Noguchi T, Ikeshima E, Shiraki M, Kanaya T, Tsuboyama-Kasaoka N,
Ezaki O, Oikawa S, Kondo K. Prevention of diet-induced obesity by dietary
isomerized hop extract containing isohumulones, in rodents. Int J Obes (Lond).
2005 Aug;29(8):991-7. PubMed PMID: 15852044.

5: Nozawa H, Nakao W, Zhao F, Kondo K. Dietary supplement of isohumulones
inhibits the formation of aberrant crypt foci with a concomitant decrease in
prostaglandin E2 level in rat colon. Mol Nutr Food Res. 2005 Aug;49(8):772-8.
PubMed PMID: 15968705.

6: Miura Y, Hosono M, Oyamada C, Odai H, Oikawa S, Kondo K. Dietary isohumulones,
the bitter components of beer, raise plasma HDL-cholesterol levels and reduce
liver cholesterol and triacylglycerol contents similar to PPARalpha activations
in C57BL/6 mice. Br J Nutr. 2005 Apr;93(4):559-67. PubMed PMID: 15946420.

7: Yajima H, Ikeshima E, Shiraki M, Kanaya T, Fujiwara D, Odai H,
Tsuboyama-Kasaoka N, Ezaki O, Oikawa S, Kondo K. Isohumulones, bitter acids
derived from hops, activate both peroxisome proliferator-activated receptor alpha
and gamma and reduce insulin resistance. J Biol Chem. 2004 Aug
6;279(32):33456-62. Epub 2004 Jun 3. PubMed PMID: 15178687.

For more information related to patented isohumulone extract contact:
info@isohumulone.com